一、课题

1. 国家自然科学基金面上项目“β淀粉样蛋白调节囊泡谷氨酸转运体功能的研究（No.81473191）”，起止时间：2015.01-2018.12。

2. 国家科技重大专项新药创制专项“以GPCR β1/β2AR等为主要靶标的经典方剂中防治阿尔茨海默病的活性成分(群)筛选及创新中药发现（No.2013ZX09508104）”，起止时间：2013.01-2015.12。

3. 国家科技重大专项新药创制专项“建立基于网络药理学的组合靶标验证和药物筛选关键技术（No.2012ZX09301003-002-001）”，起止时间：2012.01-2015.12。

4. 国家自然科学基金面上项目“囊泡谷氨酸转运体作为老年痴呆症药物新靶标的研究（No.30973541）”，起止时间：2010.01-2012.12。

5. 北京市科技新星A类计划（No.2007A061），起止时间：2007.10-2010.10。

6. 国家自然科学基金青年科学基金项目“Ⅰ型囊泡谷氨酸转运体与学习记忆相关性及其做为益智药物潜在靶标的研究（No.30600760）”，起止时间：2007.01-2009.12。

二、代表性文章

1. Jianhui Wang^#, Xi Lei^#, Zongjie Xie, Xiaorui Zhang,Xiaorui Cheng*, Wenxia Zhou*, Yongxiang Zhang. CA-30, an oligosaccharide fraction derived from Liuwei Dihuang decoction, ameliorates cognitive deterioration via the intestinal microbiome in the senescence-accelerated mouse prone 8 strain.Aging, 2019, 11(11):3463-3486.

2. Tongxing Wang^#, Lu Han, Xiaorui Zhang, Rongrong Wu,Xiaorui Cheng*, Wenxia Zhou*, Yongxiang Zhang. Knowledge-Based Neuroendocrine Immunomodulation (NIM) Molecular Network Construction and Its Application,Molecules, 2018, 23, 1312.

3. Jianhui Wang^#,Xiaorui Cheng^#*, Ju Zeng, Jiangbei Yuan, Zhongfu Wang, Wenxia Zhou*, Yongxiang Zhang. LW-AFC Effects onN-glycan Profile in Senescence Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer’s Disease,Aging and Disease, 2017, 8(1): 101-114.

4. Jianhui Wang^#, Xi Lei^#,Xiaorui Cheng^#*, Xiaorui Zhang, Gang Liu, Junping Cheng, Yiran Xu, Ju Zeng, Wenxia Zhou*, Yongxiang Zhang*. LW-AFC, a new formula derived from Liuwei Dihuang decoction, ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune system in PrP-hAβPPswe/PS1ΔE9 transgenic mice.Alzheimer's Research & Therapy, 2016, 8(1):57-72.

5. Wenxia Zhou^#,Xiaorui Cheng^#, Yongxian Zhang*. Effect of Liuwei Dihuang decoction, a traditional Chinese medicinal prescription, on the neuroendocrine immunomodulation network,Pharmacology and Therapeutics, 2016, 162(4): 170-178.

6. Cheng Xiaorui^#, Cui Xiuliang^#, Zheng Yue, Zhang Guirong, Li Peng, Huang Huang, Zhao Yueying, Bo Xiaochen, Wang Shengqi, Zhou Wenxia*, Zhang Yongxiang*. A Co-Module Regulated by Therapeutic Drugs in a Molecular Subnetwork of Alzheimer’s Disease Identified on the Basis of Traditional Chinese Medicine and SAMP8 Mice.Current Alzheimer Research, 2015, 12(9): 870-885.

7. Xiao-rui Cheng^#, Wen-xia Zhou*, Yong-xiang Zhang*. The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer’s disease animal model,Ageing Research Reviews, 2014, 13:13-37.

8. Xiaorui Cheng^#, Yu Zhou^#, Wei Gu, Jie Wu, Aihua Nie, Junping Cheng, Jinwu Zhou, Wenxia Zhou*, Yongxiang Zhang*. The selective BACE1 inhibitorⅥa reduces Aβ production in cell and mouse model of Alzheimer’s disease,Journal of Alzheimers Disease, 2013, 37(4): 823-834.

9. Jin-Wu Zhou^#,Xiao-Rui Cheng^#, Jun-Ping Cheng, Wen-Xia Zhou*, Yong-xiang Zhang*. The β-secretase activity and mRNA expression in the brain of senescence-accelerated mice.Journal of Alzheimers Disease, 2012, 28(2):471-480.

10. Xiao-Rui Cheng^#, Yong Yang, Wen-Xia Zhou*, Yong-Xiang Zhang. Expression of VGLUTs contributes to degeneration and acquisition of learning and memory. Neurobiology of Learning and Memory, 2011, 95(3):361-375.

11. Zhang Gui-rong^#,Cheng Xiao-rui, Zhou Wen-xia, Zhang Yong-xiang*. Age-related expression of calcium/calmodulin-dependent protein kinase ii-α in the hippocampus and cerebral cortex of samp8 and its response to anti-alzheimer’s disease drugs,Neuroscience, 2009, 159(1): 308-315.

12. Xiao-Rui Cheng^#, Wen-Xia Zhou*, Yong-Xiang Zhang, Dong-sheng Zhou, Rui-fu Yang, and Ling-Feng Chen. Differential gene expression profiles in the hippocampus of senescence-accelerated mouse,Neurobiology of Aging, 2007, 28 (4): 497-506.